![]() Glabrata infections have a high mortality rate in compromised, at-risk hospitalized patients. ![]() Unfortunately, there have been relatively few investigations of C. glabrata compared to other Candida species. Although this infection is second or third in frequency after C. albicans, difficult to treat, and associated with a high mortality rate, publications to date on C. glabrata account for only a small percentage of published studies on medically important fungal infections. Very little is known about the virulence of C. glabrata, and virtually nothing is known about the host defenses directed against the organism. There are only two established animal models of experimental C. glabrata infections (systemic and vaginal) ( 24, 41). Therefore, studies to understand the pathogenesis of C. This review discusses what is currently known about C. Glabrata infections and includes specific comparisons to C.
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